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Analgesic Activity and Safety Assessment of Heliotropium indicum Linn. (Boraginaceae) in Rodents

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Author(s): A. Boye | G.A. Koffuor | P. Amoateng | E.O. Ameyaw | A.K. Abaitey

Journal: International Journal of Pharmacology
ISSN 1811-7775

Volume: 8;
Issue: 2;
Start page: 91;
Date: 2012;
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Keywords: formalin-induced nociception | morphine | sub-acute toxicity | Diclofenac

ABSTRACT
This study presented the analgesic and safety assessment of Heliotropium indicum, a plant traditionally used for the management of abdominal pains, dysmenorrhoea and post-labour inflammatory conditions in Ghana using formalin-induced pain model in mice. For comparison of analgesic effect, morphine (1-10 mg kg-1) and diclofenac sodium (1-10 mg kg-1) were used as a reference opioid and NSAID, respectively. The aqueous and ethanolic extracts (30-300 mg kg-1) dose-dependently inhibited both the first and second phases of the formalin-induced nociception. Oral doses of the aqueous extract (1-5 g kg-1) in imprint control region mice were well tolerated in acute toxicity studies; however a 14-day oral administration of 1-2 g kg-1 of the extracts in sprague-Dawley rats produced pathologic effects on the heart, kidney, liver and lungs. Therefore, although the aqueous and ethanolic extracts of H. indicum have analgesic activity, it could have a cumulative toxic effects hence prolonged and continuous use is not advised.
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