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Análise de glicocorticosteróides por CG-EM: uma nova abordagem de derivatização para o controle de dopagem no esporte

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Author(s): Pereira Henrique M. G. | Marques Marlice A. S. | Cardoso Jarí N. | Aquino Neto Francisco R.

Journal: Química Nova
ISSN 0100-4042

Volume: 25;
Issue: 6b;
Start page: 1096;
Date: 2002;
Original page

Keywords: glucocorticosteroids | GC-MS | doping control

ABSTRACT
Glucocorticosteroids (CT) show a powerful anti-inflammatory effect. In view of this, they are extensively used in sports medicine, but their misuse (systemic administration) can lead to severe injuries on athletes and has been restricted by the IOC in recent years. For GC-MS analysis, a derivatization step is necessary in order to convert them to a stable form, thus preventing thermal breakdown with the loss of the ketone side chain. Derivatization of CT is reviewed and a new approach of silylation is presented for screening of CT in urine.
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