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Analysis of the action of Himatanthus drasticus in progression of urethane-induced lung cancer in mice

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Author(s): Wendy Caroline de Souza Costa França | Ana Cláudia Rodrigues Lopes Amaral de Souza | José Antônio Cordeiro | Patricia Maluf Cury

Journal: Einstein
ISSN 1679-4508

Volume: 9;
Issue: 3;
Start page: 350;
Date: 2011;
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Keywords: Lung neoplasms | Mice | Urethane | Phytotherapy | experimental

ABSTRACT
Objective: To evaluate the effect of janaguba in inhibiting thedevelopment of lung cancer in an experimental urethane-inducedmodel. Methods: a total of 3 mg/kg urethane was injected in 51 Balb-Cmice aged 7-13 weeks of life. Janaguba was administered orally dailyin two doses: 0.04 mL (Group 2, G2) and 0.06 mL (Group 3, G3), for20 weeks. After this period, the mice were sacrificed and the numberof lesions counted. Results: The mean weight of Group 2 was lowerthan that of Group 3, and that of Group 1 (Control, G1) (G1 = 35.533 g; G2 = 33.359 g; G3 = 37.125 g). The number of nodules did not differbetween groups (mean G1 = G2 = G3 = 1; p = 0.88). Conclusion:Janaguba had an effect on the growth of mice, but had no influence onthe progression of lung cancer in this model.
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