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ANALYSIS OF ANGINA PECTORIS STATUS BASED ON THE PROBABILITY OF MISCLASSIFYING THE RISK FACTOR: TEHRAN LIPID AND GLUCOSE STUDY

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Author(s): Abadi A. Mohammad K. | Meshkani M.R | Kazemnejad A. | Mehrabi Y. | Azizi F.

Journal: Journal of School of Public Health and Institute of Public Health Research
ISSN 1735-7586

Volume: 2;
Issue: 1;
Start page: 1;
Date: 2004;
Original page

Keywords: Misclassification probability

ABSTRACT
Misclassification of disease status and risk factors is one of the main sources of error in studies. Wrong assignment of individuals into exposed and non-exposed groups may seriously distort the results in case-control studies. This study investigates the effect of misclassification error on odds ratio estimates and attempts to introduce a correction method. Data on 3332 men aged 30-69 years from Tehran Lipid and Glucose Study (TLGS) were considered for investigating the relationship between angina pectoris and smoking. The “Rose” questionnaire was used to evaluate angina status. Two different definitions of smoking were included: I) active smokers versus non-smokers, II) active and ex-smokers versus never smoked. The relation between variables was assessed both with and without considering misclassification in smoking. Definition I (commonly used in many epidemiologic studies), resulted in a non-significant OR=1.09 (95% CI: 0.84, 1.41). Using the correction method based on the principle of non-differential misclassification, the OR increased to 1.13 (95% CI: 0.89, 1.43), which was still non-significant. However, a correction procedure that included the probability of differential misclassification produced a significant OR=1.46 (95% CI: 1.15, 1.85), p

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