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Angiogenesis and Ovarian Function

Author(s): Douglas DC | Nakhuda GS | Sauer MV | Zimmermann RC

Journal: Journal für Fertilität und Reproduktion
ISSN 1019-066X

Volume: 15;
Issue: 4;
Start page: 7;
Date: 2005;
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Keywords: Angiogenese | Fertilität | Follikel | Ovar | angiogenesis | fertility | follicle | ovary

Ovarian follicle development and corpus luteum formation involves recurrent, regulated, and self-limited angiogenesis. In rodent and non-human primate models it was shown that the VEGF/VEGF receptor 2 signal transduction pathway is of critical importance for ovarian angiogenesis. Clinically manipulation of this pathway might be helpful in finding new treatment methods for ovarian cancer, ovarian hyperstimulation syndrome, polycystic ovarian disease, endometriosis, as well as new, non-hormonal contraceptive approaches.
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