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Angiotensin converting enzyme inhibitors: decrease in heart remodeling and improvement in function of endothelium in patients with arterial hypertension.

Author(s): K.Yu. Nikolaev | G.I. Lifshits | A.A. Nikolaeva | I.M. Gicheva

Journal: Racionalʹnaâ Farmakoterapiâ v Kardiologii
ISSN 1819-6446

Volume: 2;
Issue: 4;
Start page: 12;
Date: 2006;
Original page

Keywords: arterial hypertension | endothelial function | vascular reactivity | enalapril

Aim. To estimate an effect of enalapril, angiotensin converting enzyme (ACE) inhibitor, on left ventricular hypertrophy and endothelium function in patients with arterial hypertension (HT).Material and methods. 41 patients with HT of I-III grade were included into the study. A part of patients received enalapril in an average daily doze of 10 mg. Parameters of microcirculatory reactivity and computer electrocardiogram analysis according to original technique were studied.Results. Microcirculatory indices showed that 6 month enalapril treatment resulted in significant improvement of disturbed function of vascular endothelium. Reduction of left ventricular hypertrophy also was demonstrated.Conclusion. ACE inhibitors should be widely recommended in hypertensive patients due to their vascular and heart remodeling positive effects.
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