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Anionic Hydrogels for Controlled Release of Transdermal Drug

Author(s): Bashir Ahmad | Shumaila Bashir | Muhammad Nisar | M.B.Huglin

Journal: Journal of Biological Sciences
ISSN 1727-3048

Volume: 3;
Issue: 3;
Start page: 298;
Date: 2003;
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Keywords: VP/IA hydrogel | pH sensitive | antifungal drug | controlled release

Anionic hydrogels, using Azo-iso butyronitrile as cross linker, with varying ionic moieties were prepared from N vinyl-2-Pyrrolidone/Methylene Succinic acid/water by heating them at different temperatures for different interval of times. Swelling/drug loading sensitivity with pH and ionic strength of the medium for these hydrogels were investigated. The results anticipate that hydrogels in the ratio of VP/IA 90:10 can be used for local therapeutic Transdermal drug delivery application of cationic, antifungal terbinafine hydrochloride (TER-HCl) in the concentration range of
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