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Antagonistic Role of Silymarin Against Cardiotoxicity and Impaired Antioxidation Induced by Adriamycin and/or Radiation Exposure in Albino Rats

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Author(s): Ahmed Rashad M.Abu Ghadeer | Samia E.Ali | Soheir A.A. Osman

Journal: Pakistan Journal of Biological Sciences
ISSN 1028-8880

Volume: 4;
Issue: 5;
Start page: 604;
Date: 2001;
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Keywords: Adriamycin | CPK | gamma radiation | MDA | rats | silymarin | SOD

ABSTRACT
Adriamycin (ADR) is one of the most potent antineoplastic agents known, however, its clinical use is limited due to its cardiotoxicity. In this investigation, the role of silymarin (flavonoid found in most plants) against the action of ADR and radiation was evaluated. ADR was injected to rats in four equal doses (3 mg/kg body weight twice a week) and after the last dose rats were exposed to whole body (6 Gy) gamma irradiation. Blood samples were taken 1 and 10 days after radiation exposure. Silymarin was orally administered 10 days before ADR injection. ADR and radiation have dramatic effects on the blood level of lactate dehydrogenase (LDH), creatinine phosphokinase (CPK), indicating heart toxicity, as well as on the content of malondialdehyde (MDA) & glutathione (GSH) and the activity level of gluathione peroxidase (GSH-Px) & superoxide dismutase (SOD), indicating depression in the antioxidant system. The effect was more deleterious on the 10th day than the 1st day of investigation (indicating late and continuos action of ADR and radiation). Production of free radicals of both ADR and radiation may be the main cause of the altered biochemical levels of the assayed parameters. Daily intubation of silymarin reduced the alterations in the assayed biochemical parameters induced by ADR and/or radiation in rats.
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