Author(s): Bhattacharjee Prasenjit | Hullatti K.K. | Vijay Kumar M.L.
Journal: International Journal of Research in Ayurveda and Pharmacy
ISSN 2229-3566
Volume: 2;
Issue: 1;
Start page: 181;
Date: 2011;
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Keywords: Coleus amboinicus | anthelmintic | Pheritima posthuma | Piperazine citrate | albendazole | antioxidant.
ABSTRACT
The present study reports anthelmintic activity of alcoholic extracts of leaf, stem and root of Coleus amboinicus against Indian earthworms Pheritima posthuma. The results revealed that all the tested extracts of Coleus amboinicus possessed significant anthelmintic activity in a dose-dependent manner. The activities were comparable with the reference drug Piperazine citrate and Albendazole. Among the tested extracts, the leaf extract was found to be more promising in comparison to stem and root extracts. Hence the present study justifies its use in the folklore remedies as an anthelmintic drug. Whereas, antioxidant activity of the extracts were performed by four methods, DPPH free radical scavenging activity, Hydrogen-peroxide scavenging activity, nitric oxide scavenging activity and Reducing power assay using Ascorbic acid as standard. The antioxidant potency was found to be maximum with leaf extracts in all the models among all the three extracts.
Journal: International Journal of Research in Ayurveda and Pharmacy
ISSN 2229-3566
Volume: 2;
Issue: 1;
Start page: 181;
Date: 2011;
VIEW PDF
DOWNLOAD PDF Original pageKeywords: Coleus amboinicus | anthelmintic | Pheritima posthuma | Piperazine citrate | albendazole | antioxidant.
ABSTRACT
The present study reports anthelmintic activity of alcoholic extracts of leaf, stem and root of Coleus amboinicus against Indian earthworms Pheritima posthuma. The results revealed that all the tested extracts of Coleus amboinicus possessed significant anthelmintic activity in a dose-dependent manner. The activities were comparable with the reference drug Piperazine citrate and Albendazole. Among the tested extracts, the leaf extract was found to be more promising in comparison to stem and root extracts. Hence the present study justifies its use in the folklore remedies as an anthelmintic drug. Whereas, antioxidant activity of the extracts were performed by four methods, DPPH free radical scavenging activity, Hydrogen-peroxide scavenging activity, nitric oxide scavenging activity and Reducing power assay using Ascorbic acid as standard. The antioxidant potency was found to be maximum with leaf extracts in all the models among all the three extracts.