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Anthracenedione Derivatives as Anticancer Agents Isolated from Secondary Metabolites of the Mangrove Endophytic Fungi

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Author(s): Jian-ye Zhang | Li-yang Tao | Yong-ju Liang | Li-ming Chen | Yan-jun Mi | Li-sheng Zheng | Fang Wang | Zhi-gang She | Yong-cheng Lin | Kenneth Kin Wah To | Li-wu Fu

Journal: Marine Drugs
ISSN 1660-3397

Volume: 8;
Issue: 4;
Start page: 1469;
Date: 2010;
Original page

Keywords: mangrove endophytic fungi | anthracenedione derivatives | anticancer | apoptosis | structure-activity relationship

ABSTRACT
In this article, we report anticancer activity of 14 anthracenedione derivatives separated from the secondary metabolites of the mangrove endophytic fungi Halorosellinia sp. (No. 1403) and Guignardia sp. (No. 4382). Some of them inhibited potently the growth of KB and KBv200 cells, among which compound 6 displayed strong cytotoxicity with IC50 values of 3.17 and 3.21 μM to KB and KBv200 cells, respectively. Furthermore, we demonstrate that the mechanism involved in the apoptosis induced by compound 6 is probably related to mitochondrial dysfunction. Additionally, the structure-activity relationships of these compounds are discussed.

Tango Jona
Tangokurs Rapperswil-Jona

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