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ANTI-ALZHEIMER POTENTIAL OF ORANGE JUICE

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Author(s): Parle Milind | Chaturvedi Dev

Journal: International Research Journal of Pharmacy
ISSN 2230-8407

Volume: 3;
Issue: 9;
Start page: 312;
Date: 2012;
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Keywords: Citrus sinensis | Memory | Morris water maze.

ABSTRACT
Orange (Citrus sinensis) is well known for its nutritional and medicinal properties throughout the world. This study was undertaken to test the effect of orange juice on the memory of mice. A total of 228 mice divided in 38 groups were employed in this study. Orange juice (2.5%, 5%, 7.5%, 10% v/v) was administered orally to mice with the help of an oral feeding needle. Morris water maze, elevated plus maze and object recognition task served as exteroceptive behavioral models, whereas scopolamine -induced amnesia and alprazolam -induced amnesia served as interoceptive memory models. Brain AchE activity was measured using Ellman’s method. Orange juice significantly (p< 0.01) reduced transfer latency of mice in Elevated plus maze model. In another experimental model, orange juice significantly (p
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