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Anti-carcinogenic Effect of Solanum trilobatum in Diethylnitrosamine Induced and Phenobarbital Promoted Heaptocarcinogenesis in Rats

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Author(s): M.S. Jahan | G. Vani | C.S. Shyamaladevi

Journal: Asian Journal of Biochemistry
ISSN 1815-9923

Volume: 6;
Issue: 1;
Start page: 74;
Date: 2011;
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Keywords: Beta solamarine | antitumor | carcinoembryonic antigen | N-diethylnitrosamine (DEN) | Hepatocarcinogenesis | marker enzymes | Solanum trilobatum | sobatum | solasodine

ABSTRACT
Solanum trilobatum (ST) prevented 2 stage carcinogenesis in Wistar rats induced by diethyl nitrosamine (DEN) and promoted with Phenobarbital (PB). Animals were induced for hepatic carcinoma with DEN (200 mg kg-1 b.wt. i.p.,), promoted with PB (0.05%) in basal diet for a period of 3 and 6 months. Animals were also co-treated with methanolic extract of ST (250 mg kg-1 b.wt. in DMSO orally) for the same period of time (DEN+PB+ST). Administration of ST significantly decreased the levels of tumor markers-carcinoembroynic antigen (CEA) and a-fetoprotein (AFP) in serum compared to their untreated counterparts and also favorably altered the marker enzymes AST, ALT, ALP, GGT and LDH in both serum and liver and 5nucleotidase in liver. These results show the antitumor effect of ST against DEN induced hepatocarcinogenesis.]]>
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