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Anti-Clastogenic Effects of Citral

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Author(s): Syed Imam Rabbani | Kshama Devi | Noor Zahra

Journal: Iranian Journal of Pharmacology and Therapeutics
ISSN 1735-2657

Volume: 4;
Issue: 1;
Start page: 28;
Date: 2005;
Original page

Keywords: Citral | Antimutagenicity | Micronucleus test | Clastogens

ABSTRACT
Citral is a major constituent of Cymbopogon citratus or lemongrass oil. The anti-clastogenic effect of citral (20 mg/kg) was tested against the known mutagens cyclophoshamide, mitomycin-C and nickel metal (NiCl2) in mice. Micronucleus (MN) frequency was evaluated in both bone marrow and peripheral blood erythrocytes. The sampling was done after 24 h, 48 h and 72 h of clastogen treatment. Results show that citral had significantly (p < 0.01) decreased the frequency of MN induced by the three clastogens in bone marrow and peripheral blood erythrocytes.
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