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Anti-Diabetic Activity of Cynanchum acutum Extract in Alloxan-Induced Diabetic Rats

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Author(s): Jasem Estakhr | Fereshteh Javadian | Zohre Ganjali | Mehdi Dehghani | Abbas Heidari

Journal: International Journal of Animal and Veterinary Advances
ISSN 2041-2894

Volume: 4;
Issue: 4;
Start page: 303;
Date: 2012;
Original page

Keywords: Anti-diabetic activity | alloxan-induced diabetic rat | Cynanchum acutum

ABSTRACT
The present study investigates the anti-diabetic potential of Cynanchum acutum extract in alloxaninduced diabetic rats. The effects of an ethanolic extract of Cynanchum acutum on serum glucose, total cholesterol, triglycerides, plasma insulin and liver glycogen were examined in control and experimental groups. Cynanchum acutum extract reduced the serum glucose concentration at 24, 48 and 72 h. To verify the activity sub-chronically, the extract administered orally in the doses of 25, 50 and 100 mg/kg to diabetic rats for 30 days, that significantly reduced the level of glucose, total cholesterol and triglycerides with an increase in insulin and glycogen concentration to near normal levels in a dose-dependent manner. The results indicate that Cynanchum acutum extract possess anti-diabetic potential in alloxan-induced diabetic rats.
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