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Anti-diabetic effects of OZG (A polyherbal formulation of indigenous plants ) in streptozotocin induced diabetic rat.

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Author(s): *1Bhawani Goru, 2Rajkumar Goel, 3Ashutosh Kumar, 4V K Joshi

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 10;
Start page: 3312;
Date: 2011;
Original page

Keywords: Diabetic Rat | Polyherbal Drug

ABSTRACT
The present study was designed to investigate the effect of OZG, a polyherbal drug, on blood glucose, plasma insulin and other biochemical parameters inblood and serum, of streptozotocin induced diabetic rats. Methods: Inbred charles foster strain albino rats (150-200 g) of male sex were used for the experiment.First step was to conduct the dose response study on blood glucose (BGL), total cholesterol (TC) and triglycerides (TGL). It was conducted using dosages 30 mg/kg bd. wt. 100 mg / kg bd. wt. and 300 mg/kg bd. wt at a volume 1 ml/100 mg bd.wt for a period of 28 days. Mild (NIDDM) and severe (IDDM) diabetes were inducedin adult rats by injecting 45 mg / kg and 70 mg/kg of streptozotocin (STZ) I.P respectively. After calculating the ED50 through the Dose response curve (DRC),the effective dose was used to observe the effect of OZG on various biochemical and General parameters. The perse effect was also noted. The OZG test drug wascompared for its efficacy with the standard drug Glibenclamide (600 ug/kg bd wt) in cases of mild diabetes and with insulin (4U/kg bd.wt) in case of severe diabetes.Results: Treatment with OZG resulted in significant reduction in blood glucose and brought to normalcy the other deranged biochemical parameters and the antioxidantstatus as effectively as the standard drugs Glibenclamide in mild diabetes and Insulin in severe diabetes.
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