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Anti-hepatotoxic and anti-oxidant defense potential of Tridax procumbens

Author(s): Hemalatha Reddipalli

Journal: International Journal of Green Pharmacy
ISSN 0973-8258

Volume: 2;
Issue: 3;
Start page: 164;
Date: 2008;
Original page

Keywords: Anti-hepatotoxicity | anti-oxidant | ethanolic extract | Tridax procumbens

Tridax procumbens is a widely occurring medicinal herb used by ethnomedical practitioners. With increased use of chemicals and alcohol besides growing incidence of viruses and autoimmune diseases, the incidence of liver injury is growing for which conventional drugs used for treatment are often inadequate. Various models are adopted in pharmological studies for inducing hepatitis/ liver injury similar to those observed in human viral hepatitis, diabetes and oxidative stress. D-galactosamine with lipopolysacchride (LPS), carbontetrachloride (CCl 4 ) and paracetamol intoxication, diabetes induced with alloxan are widely used on rodents for this purpose. In vitro studies on Tridax procumbens (TP) revealed the anti-oxidant potential of the herb with chloroform fraction of the ethanolic extract showing maximum activity. It is also reported to possess anti-oxidant minerals such as iron, magnesium, copper and zinc. In vivo studies on rodents on the anti-oxidant potential of TP induced through LPS, CCl 4, alloxan and paracetamol intoxication induced hepatitis confirmed the results from in vitro studies as a potential anti-hepatotoxic herb.
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