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Anti-HIV-1 integrase activity of Thai medicinal plants in longevity preparations

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Author(s): Kingkan Bunluepuech | Supinya Tewtrakul*

Journal: Songklanakarin Journal of Science and Technology
ISSN 0125-3395

Volume: 33;
Issue: 6;
Start page: 693;
Date: 2011;
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Keywords: anti-HIV-1 integrase activity | longevity preparation | Thai plants

ABSTRACT
For the purpose of discovering anti-HIV-1 agents from Thai plant preparations with a history of use in Thai traditionalmedicine as agents assisting longevity, the aqueous and EtOH extracts from 24 Thai plants were screened for their inhibitoryactivities against HIV-1 integrase (IN) using the multiplate integration assay (MIA). 11 extracts (23%), 5 ethanol and 6 water,from 8 plants Albizia procera, Areca catechu, Bauhinia strychnifolia, Betula alnoides, Blumea balsamifera, Caesalpiniasappan, Cassia garrettiana and Stephania venosa, produced extracts with IC50 values of < 20 μg/ml. 27 extracts (56%) hadno detectable activity with IC50 values >100 μg/ml, while 10 extracts (21%) had IC50 values of between 20-97.2 μg/ml. Both theEtOH and water extracts of Cassia garrettiana (heartwood) and Bauhinia strychnifolia (vine), were the most potent withIC50 values of 3.0 and 5.2 μg/ml, and 6.4 μg/ml and 11.2 μg/ml, respectively. The isolation of active principles against HIV-1 INfrom Cassia garrettiana and Bauhinia strychnifolia is now being further investigated.
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