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Anti-hyaluronidase, Anti-elastase Activity of Garcinia indica

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Author(s): Abhijit Sahasrabudhe | Manjushree Deodhar

Journal: International Journal of Botany
ISSN 1811-9700

Volume: 6;
Issue: 3;
Start page: 299;
Date: 2010;
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Keywords: hyaluronidase | antioxidant | fruit extract | flavonoids | ageing | ECM | PPE

ABSTRACT
During ageing, elasticity of the skin decreases due to enzyme elastase leads to sagging and at the same time hyaluronic acid in the skin also diminishes and skin becomes dry and wrinkled. Hence, there is need to conserve matrix metallo proteins by inhibiting the activity of these matrix metallo proteinases. Certain plant extracts are reported to be good antioxidants. Garcinol and cambogiol present in the fruit rinds of Garcinia indica were reported to be good antioxidants due to presence of phenolic group. Along with this various preparations of G. indica have shown significant antioxidant ability. To check whether fractions separated from fruit rinds of G. indica play a role in prolonging ageing, we fractionated crude Methanolic Extract (ME) into ethyl acetate and Water Fraction (WF) and those fractions were screened for anti-hyaluronidase and anti-elastase activity. Among tested three fractions, Ethyl Acetate Fraction (EAF) at concentrations as low as 25 μg mL-1 showed significant hyaluronidase inhibition while water fraction proved to be good elastase and hyaluronidase inhibitor at 90 μg mL-1. Water fraction could be further exploited to be used in anti-ageing formulations.
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