Academic Journals Database
Disseminating quality controlled scientific knowledge

Anti-Hyperglycemic and Renal Protective Activities of Andrographis paniculata Roots Chloroform Extract

ADD TO MY LIST
 
Author(s): Nalamolu Koteswara Rao

Journal: Iranian Journal of Pharmacology and Therapeutics
ISSN 1735-2657

Volume: 5;
Issue: 1;
Start page: 47;
Date: 2006;
Original page

Keywords: Alloxan | Blood glucose | Rats | Albuminuria | Proteinemia | Uremia

ABSTRACT
The chloroform extract of Andrographis paniculata roots was tested for its antihyperglycemic activity in alloxan induced diabetic rats using chronic and acute studies. The blood glucose lowering activity was determined after oral administration at doses of 50, 100 and 150 mg/kg body weight in acute study. Where as in case of chronic study blood glucose, protein, albumin and creatinine levels were estimated after 4 weeks of treatment at the dose of 300 mg/kg. Significant reductions in blood glucose levels were observed in both acute and chronic studies. The extract significanly inhibited the induction of albuminuria, proteinemia and uremia. The present study clearly indicated a significant antidiabetic activity with the chloroform extract of A. paniculata roots and supports the traditional usage of the plant by Ayurvedic physicians for the control of diabetes. Also the extract is useful in preventing the incidence of long-term complication, diabetic nephropathy.
Save time & money - Smart Internet Solutions     

Tango Jona
Tangokurs Rapperswil-Jona