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Anti-inflammatory and analgesic activity of Balanites aegyptiaca in experimental animal models

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Author(s): Gaur Kalpesh | Nema R | Kori M | Sharma C | Singh Virendra

Journal: International Journal of Green Pharmacy
ISSN 0973-8258

Volume: 2;
Issue: 4;
Start page: 214;
Date: 2008;
Original page

Keywords: Balanites aegyptiaca | indomethacin | inflammation | pain | paw edema

ABSTRACT
The anti-inflammatory and analgesic effect of ethanolic and petroleum ether extracts of Balanites aegyptiaca were evaluated in experimental animals. We have determined the anti-inflammatory and analgesic activity of ethanolic and petroleum ether extracts of dried aerial parts of Balanites aegyptiaca by oral administration at doses of 300 and 600 mg/kg/day of body weight to healthy animals. The extracts were studied for their anti-inflammatory activity in carrageenan-induced hind paw edema in rats and the paw volume was measured plethysmometrically at 0 and 3h after injection. The ethanolic and petroleum ether extracts were also evaluated for analgesic activity using Eddy′s hot plate method and tail-flick method in albino rats. The ethanolic and petroleum ether extracts of Balanites aegyptiaca, significantly (P< 0.05) reduced carrageenan-induced paw edema in rats and analgesic activity evidenced by increase in the reaction time by Eddy′s hot plate method and tail-flick method in albino mice. The ethanolic and petroleum ether extracts showed a greater anti-inflammatory and analgesic effect comparative to the standard drugs, indomethacin and diclofenac sodium respectively. The present results indicated the ethanolic extract of Balanites aegyptiaca exhibited more significant activity than petroleum ether in the treatment of pain and inflammation.
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