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Anti-Inflammatory and Analgesic Effects of Leaf Extracts of Hibiscus Populnea Linn.

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Author(s): Hareeshbabu E | Molly Mathew

Journal: International Journal For Pharmaceutical Research Scholars
ISSN 2277-7873

Volume: 2;
Issue: 3;
Start page: 174;
Date: 2013;
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Keywords: Hibiscus populnea | acute toxicity | antiarthritic | anti-inflammatory | nociceptive effect

ABSTRACT
Hibiscus populnea or Indian Tulip Tree or Pacific Rosewood, has been traditionally used for thetreatment of many diseases including inflammatory conditions. A number of chemical constituentsnamely, thespesin, gossypol, DL-gossypol, populnin, populneol, glycosides of quercetin, epoxylic acid,rutin, kaemferol-3-flucoside, lupenone, mansonone, myricyl alcohol, lipids and β sitosterol have beenisolated from the plant. Many of these compounds are proved to have the claimed activities. But nowork has been specifically carried out to establish the anti inflammatory effects of the ripe and olderleaves. Hence in the present study an attempt was made, with the leaves, for the phytochemicalscreening of the methanol, pet. ether and aqueous extracts along with their anti-inflammatory andanalgesic potential also. In order to study the anti-inflammatory effects, dextran-induced paw edemamethod and carrageenan - induced paw edema methods were used. Similarly analgesic activity wastested using acetic acid writhing. Anti arthritic study was also tried. Regarding carrageenan- inducedpaw edema, the level of activity of the petroleum ether extract was less than that of the reference drugand the methanolic extract exhibited the most potent inhibitory activity. But the activity of the aqueousextract was more than that of Indomethacin. From the results of the experimentally induced arthriticstudy it was seen that the activity of the petroleum ether extract was quite stable throughout the period ofassay where as the methanolic extract was proved to be more active against the chronic phase thanagainst the acute phase. The aqueous extract was seen to be a very potent anti inflammatory agentagainst both phases of the inflammatory process with more or less the same activity as that ofindomethacin, the reference standard. The analgesic activities of aqueous and methanolic extracts werefound to be very significant (P < 0.001).
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