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Anti-inflammatory and Anti-ulcerogenic effect of Crotalaria juncea Linn. in albino rats.

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Author(s): Purnima Ashok | GP Rajani | Arulmozhi Sinnathambi | Basavaraj Hulkoti | Babasaheb Desai | R Rajendran

Journal: Iranian Journal of Pharmacology and Therapeutics
ISSN 1735-2657

Volume: 5;
Issue: 2;
Start page: 141;
Date: 2006;
Original page

Keywords: Crotalaria juncea | Antiarthritic | CFA

ABSTRACT
Crotalaria juncea (Leguminoceae) has been used for its antiarthritic effect in the folklore medicine. The purpose of this study was investigating experimentally the possible antiarthritic and antiulcerogenic properties of Crotalaria juncea leaves in animal model. Ethanolic extract of Crotalaria juncea (CJE) was administered at the doses of 200 and 400 mg/kg to complete Freund’s adjuvant (0.1 ml) induced arthritic rats. The effect of CJE, compared with standard indomethacin was measured. Treatment with CJE decreased the inflammation compared to the standard group. Antiulcerogenic potential of CJE was also evaluated. The CJE treated animals were protected from ulcer formation whereas indomethacin group of animals showed ulcer formation. The present study indicates that the ethanol extract of Crotalaria juncea exhibit significant antiarthritic and antiulcerogenic activities.
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