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Anti-inflammatory and cicatrizing activity of Baphia nitida Lodd. exudates

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Author(s): Konkon N’dri Gilles 1,2 , Ouattara Djakalia 2 , Adjoungoua Attoli Léopold 1 , Simaga Dédéou 1 , Koné Bamba 1 , N’guessan Kouakou Edouard 2 , Kouakou Tanoh Hilaire 3*

Journal: International Journal of Biosciences
ISSN 2220-6655

Volume: 1;
Issue: 5;
Start page: 45;
Date: 2011;
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Keywords: Anti-inflammatory activity | Baphia nitida | cicatrizing activity | exudates | wound healing.

ABSTRACT
Baphia nitida exudate (BNE) is used in folk medicine for the treatment inflammation and cicatrisation of wounds in Côte d’Ivoire. BNE was formulated into an ointment and tested at two dose levels for antiinflammatory and cicatrizing activity against excision wounds created on dorsal areas of rats. Both provide evidence for the ability of BNE to inhibit the inflammatory condition and to accelerate wound cicatrization on the rats. The activity was found to be dose related, and BNE at 2% was found to be best dose for the two tests used. Phenylbutazone cream used as a positive control reference was significantly active in both systems. These results provide a scientific basis for the traditional use of the exudate of Baphia nitida as an anti-inflammatory and cicatrizing agent.
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