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Anti-inflammatory Steroid (Prednisolone) and its Effect on the Adrenal Gland

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Author(s): A.E. Essay | S.A. Sakr | S.A. Sakr | A.T. Saleh | F. El-Salmy

Journal: Pakistan Journal of Biological Sciences
ISSN 1028-8880

Volume: 3;
Issue: 9;
Start page: 1511;
Date: 2000;
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Keywords: steroid | adrnal gland | anti-inflammatory

ABSTRACT
Administration of an anti-inflammatory steroidal drug prednisolone- (0.85 mg/ kg body weight daily for 10 days) to adult toads Bufo tibamicus resulted in suppression of the function of the adrenal gland, as shown by a significant increase in the lipid droplets, autolysis of mitochondria and disorganization and degranulation of ER in the steriodogenic cells. Furthermore, chromaffin cells (catecholamines secreting cells), showed a marked decrease in the number of chronaffin granules and degenerative changes in the nuclei. These serious side effects should be taken into consideration when using this drug.
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