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The Anti-Oxidant Effects of Sevoflurane Anaesthesia and Surgery: A Preliminary Study

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Author(s): S.H. Omar | M.A. Abo Sedira | M.A. Youssif | M. Zeidan | A.M. Desoukhy | G.G. El-Fandy

Journal: Journal of Medical Sciences
ISSN 1682-4474

Volume: 8;
Issue: 7;
Start page: 641;
Date: 2008;
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Keywords: Sevoflurane | oxidative status | malondialdehyde | superoxide dismutase | glutathione peroxidase | total anti-oxidant status

ABSTRACT
This study was designed to assess influence of sevoflurane and surgery on the anti-oxidant balance in humans. Fifteen adult Class I/II of the American Society of Anaesthesiologists (ASA) patients scheduled for inguinal herniorrhaphy under sevoflurane induction followed 15 min later by sufentanyl-vecuronium supplementation were recruited. Oxidant biomarker malondialdehyde (MDA) and anti-oxidant biomarkers [superoxide dismutase (SOD), glutathione peroxidase (GSHPx) and total anti-oxidant status (TAO)] in plasma were measured. Mean values at various sampling times were compared to base-line values and showed a significant reduction in mean SOD 60 min post-induction, while at 24 h post-operatively showed a significant rise. Following induction of anaesthesia and throughout surgery, mean GSHPx increased significantly at 10 min and at end of anaesthesia. To the contrary, by 24 h post-operatively, it dropped significantly. Mean TAO showed a significant elevation at all times except at end of surgery. MDA was significantly reduced at end of surgery and at 24 h. The results of this study support the anti-oxidant property of sevoflurane anaesthesia in humans and describe the impact of anaesthesia and surgery on the measured biomarkers. Further studies are required to confirm the anti-oxidant properties of sevoflurane anaesthesia with and without surgery for a longer period of time and at different sevoflurane concentrations during various types of surgery with more emphasis on the time course of these changes during the post-operative period.
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