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Anti-Ulcer and anti-secretory Properties of the Butea Monosperma (Lam) Bark Extract with Relation to anti-oxidant Studies

Author(s): Prakash Patil | T. Prakash | H. Shivakumar | Siddhartha Pal

Journal: Iranian Journal of Pharmacology and Therapeutics
ISSN 1735-2657

Volume: 8;
Issue: 1;
Start page: 1;
Date: 2009;
Original page

Keywords: Butea Monosperma | Anti-Ulcer | Anti-Secretary | In Vitro Anti-Oxidant

To investigate the ulcer protective and antisecretory properties of the methanolic extract of Butea monosperma (BM) bark with relation to antioxidant studies. The study was done on male albino rats. Gastric ulcers were induced by Aspirin, Alcohol and Pylorous ligation. Lansoprazole was used as the standard drug for comparison. The free radical scavenging potential of the bark of BM extract was studied by using different In vitro antioxidant models of screening. The methanolic extract at 500µg/ml showed maximum free radical scavenging was estimated by lipid per oxidation, reducing power, superoxid anion and hydroxyl scavenging activity. Treatment with BM extract in different doses, significantly protected the ulceration induced by aspirin, alcohol along with ulceration induced by pyloric ligation models. Ant-secretary studies in pyloric ligated rats revealed that BM extract (in two different doses) significantly reduced total acidity, free acidity and gastric output. The pH of gastric secretion significantly increased in treatment of BM extract. The methanolic extract of BM bark possesses significant antiulcer and anti-secretory activities. Its antioxidant is also significantly stimulatory in different models.
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