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Anti tussive effect of Adhatoda vasaka & Glycyrrhiza glbra on sulfur dioxide gas induced cough reflex in mice

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Author(s): M.S.Harsoliya *1, S. Singh2, V.M.Patel3, J.K. Pathan4, D. Bhatt5, S. A. Siddiqui6

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 6;
Start page: 1880;
Date: 2011;
Original page

Keywords: Anti tussive effect | Adhatoda vasaka | Glycyrrhiza glbra | Dextromethorphan

ABSTRACT
The aim of the present study was to examine the antitussive activity of the water extract of Adhatoda vasaka (Ardusi) & Glycyrrhiza glbrain (Jethimadh) in mice. This plant helpful in pediatric, breastfeeding mother, and pregnant women and also in treating various disease and disorders viz. In this formulation uses two different multi uses plants. They were used in other than cough preparation. The efficacy of Adhatoda vasaka & Glycyrrhiza glbrain reducing cough frequency in mice. In this work performed Sulfur dioxide gas induce model. It stimulates sensory end organs arising in the trachea and bronchi; these fibers are believed to arise from the cough receptors. Thus it produce cough by stimulating sensory end organs in the trachea and bronchi. At low concentrations it causes bronchoconstriction which depends on intact motor parasympathetic pathways. The results showed that the water extract of Adhatoda vasaka & Glycyrrhiza glbra the oral dose of 100 mg.kg b.w had a cough-suppressive effect. It caused a significant (p value) decrease of the number of cough. The antitussive activity of the of Adhatoda vasaka & Glycyrrhiza glbra similar to that of the non-narcotic antitussive agent Dextromethorphan.
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