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Anti Ulcerogenic Effect of the Rhizomes of Zingiber officinale Against Ethanol Induced Gastric Ulcers in Rats

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Author(s): Mahmood, A.A. | K.Philip | I.Salmah

Journal: Journal of Animal and Veterinary Advances
ISSN 1680-5593

Volume: 5;
Issue: 2;
Start page: 122;
Date: 2006;
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Keywords: Gastric ulcer | Zingiber officnale | cimetidine

ABSTRACT
The effects of methanolic extract of the rhizomes of Zingiber officinale were studied in rats for their ability to inhibit gastric lesions induced by ethanol. Animals pre-treated with ginger root extract significantly inhibited gastric lesions compared to control rats. The root extract at a dose of 1000 mg kg 1 orally exert highly significant cytoprotection against ethanol-induced gastric lesions compared to 500 mg kg 1. This cytoprotection was accompanied with increase in mucus synthesis by gastric mucosa grossly when compared with the control rats. These observations strongly suggest cytoprotective effect of the ginger extract against ethanol-induced gastric ulcer in rats.
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