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Antiarthritic activity of hydroalcoholic seed extract of Cassia tora Linn.

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Author(s): Neelam Balekar | Anil Kumar Pasi | Gaurav Parihar | DK Jain

Journal: Topclass Journal of Herbal Medicine
ISSN 2315-8840

Volume: 2;
Issue: 11;
Start page: 254;
Date: 2013;
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Keywords: Rheumatoid arthritis | C. tora | Complete Freund’s adjuvant

ABSTRACT
The hydroalcoholic (70%) extract of seeds of Cassia tora (at different doses 100, 250 and 500 mg/kg, body weight) was screened for antiarthritic activity. In Complete freund's adjuvant (CFA) induced arthritis model degree of inflammation was evaluated by hind paw swelling, body weight measurement, haematological parameters and supported by radiological and histopathological analysis. Treatment with extracts of C. tora showed dose dependant and significant (p < 0.05) inhibition of edema in adjuvant induced arthritic rats. Hydroalcoholic extract of seeds of C. tora at a dose of 500 mg/kg body weight showed most potent and significant activity which is supported by the results analysis in complete freund's adjuvant arthritis model. The extract was qualitatively analyzed for alkaloids, flavonoids and phenols and the contents were found to be greater in ethanolic than aqueous extracts. The normal architecture of joints has been ameliorated by oral application of hydroalcoholic extract. Thus the extract possesses antiarthritic activity which may be attributed  to the presence of alkaloids, phenols and flavonoids of the plant.
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