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Antibacterial Activity and Cytotoxicity Screening of Sumatran Kaduk (Piper Sarmentosum Roxb)

Author(s): E. Atiax | F Ahmad | H. M. Sirat | D. Arbain

Journal: Iranian Journal of Pharmacology and Therapeutics
ISSN 1735-2657

Volume: 10;
Issue: 1;
Start page: 1;
Date: 2011;
Original page

Keywords: Piperaceae | P. Sarmentosum | Amides | Antibacterial | Cytotoxicity

Phytochemical investigations of Piper sarmentosum Roxb., yielded four compounds; three amides, identified as 3-(3’,4’,5’-trimethoxyphenylpropanoyl) pyrrolidine, 3-(4’-methoxyphenylpropanoyl) pyrrole, N-(3-phenylpropanoyl) pyrrole and a sterol namely β-sitosterol. 3-(4’-Methoxyphenylpropanoyl) pyrrole was found for the first time in this Piper species. All chemical constituents were tested for their antibacterial activity using disk diffusion method and cytotoxicity screening using sul-forhodamine B (SRB) assay. All of the compounds were found only active towards gram-positive bacteria except 3-(4’-methoxyphenylpropanoyl) pyrrole with no activity against both gram-positive and gram-negative bacteria. Meanwhile, the cytotoxicity screening using SRB assay indicated that none of these compounds was active as an anticancer agent.

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