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Antibacterial, antifungal, antioxidant and phytochemical study on the leaves extract of Grewia optiva

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Author(s): Shefali Arora*

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 9;
Start page: 3130;
Date: 2011;
Original page

Keywords: Grewia optiva | Antibacterial activity | Antifungal activity | Antioxidant activity.

ABSTRACT
The World Health Organization estimates that 80% of the world’s population presently uses herbal medicine for some aspect of primary health care. The useof, and search for, drugs and dietary supplements derived from plants have accelerated in recent years.The genus Grewia is mainly associated with triterpenoidsand alkaloids. Various parts of the plants has been used to treat many diseases. In continuation of this, the work is being pursued on the phytochemical,antimicrobial and antioxidant investigation on the leaves of Grewia optiva.Successive extraction of the crushed leaves of the plants has been done with varioussolvents viz. petroleum ether, benzene, chloroform, acetone, methanol and water respectively. The different extracts of the leaves of Grewia optiva weretested quantitatively. Some new phytoconstituents: Fats and fixed oils were found in Petroleum ether, benzene, chloroform, acetone, methanol and waterextract; Protein and amino acids were found in acetone, methanol and water extract and Saponins was found in methanol and water extract.These extracts werefurther tested for their antimicrobial activity against the bacterial strains of Escherichia coli, Klebsiella pneumonaie., Pseudomonas aeruginosa, Proteusmirabilis and against the fungal strains of Aspergillus niger, Microsporus gypseum, Rhizopus stolonifer, Aspergillus japanicus and Penicillum chrysogenum .Theresults have shown that the all extracts showed very good activity against the bacterial strains of Pseudomonas aeruginosa and methanol extract can act asstandard drug against this strain as it showed more inhibition zone than the standard drug doxycycline. The extract showed very weak activity against all thetested fungal strains.They showed no remarkable antioxidant activity in methanol and acetone extract.
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