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Antibacterial, antioxidant and acute toxicity tests on flavonoids extracted from some medicinal plants

Author(s): Akroum Souâd | Bendjeddou Dalila | Satta Dalila | Lalaoui Korrichi

Journal: International Journal of Green Pharmacy
ISSN 0973-8258

Volume: 4;
Issue: 3;
Start page: 165;
Date: 2010;
Original page

Keywords: Acute toxicity | antibacterials | antioxidants | flavonoids | identification | plants

Flavonoids are well-known for their many therapeutic and pharmaceutical effects. In this study, we tested the antibacterial activity of 11 flavonoids extracted from some medicinal plants by the agar diffusion method. Then, we measured their antioxidant activity using the DPPH (2,2′-diphenyl-1-picrylhydrazyl) radical assay and we also tested their acute toxicity effect on mice. The results showed that apigenin-7-O-glucoside was more active against the Gram-positive bacteria and quercetin was more active against the Gram-negative ones. Also, quercetin and diosmin showed the best antioxidant activity. Quercetin, apigenin-7-O-glucoside, luteolin-7-O-glucoside and luteolin-3′-O-glucuronide gave the best acute toxicity values. It can be concluded that quercetin was the most interesting compound for all the tested activities. Also, we observed that the presence or the absence of substitutions in flavonoids influenced significantly the results obtained, whereas the substitution type had a low impact.
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