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Antibiotic Susceptibility Pattern and Beta-lactamase Production in Isolates of Staphylococcus aureus from Recurrent Furunculosis in Southwestern, Nigeria

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Author(s): Okunye OL | Adeleke OE | Adegoke OA | Adeyemi OH

Journal: Sierra Leone Journal of Biomedical Research
ISSN 2076-6270

Volume: 3;
Issue: 3;
Start page: 123;
Date: 2011;

Keywords: Antibiotic susceptibility | β-lactamase | Recurrent furunculosis | Staphylococcus aureus

ABSTRACT
Furuculosis is a skin infection caused by Staphylococcus aureus. It is characterised by honey crusted ‘cropped’ latent boil with potential to recur in a susceptible host. Isolates of S.aureus obtained from both hospitalised and non-hospitalised patients with furuncles in Southwest, Nigeria were characterised in relation to their resistance to commonly used antimicrobial agents. Exudates of ‘cropped-boils’ from one hundred and forty (140) individuals consisting of forty (40) hospitalised and one hundred (100) non-hospitalised cases of recurrent furunculosis were screened for S. aureus. One hundred and two (102) were positive for the organism by conventional biochemical tests. Detection of β-Iactamase was determined by cell-suspension iodometric method. Of the 102 isolates, 30(29.4%) strains possessed β-lactamase and the minimum inhibitory concentration (MIC) of selected antibiotics was in the range of 3.95– 250µg/ml. The multiple drug resistance as evident in high MICs of the antibiotics tested could probably be due to abuse/misuse of antibiotics resulting in recurrence of furuncles in the patients.
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