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Anticancer-cytotoxic activity of saponins isolated from the leaves of Gymnema sylvestre and Eclipta prostrata on HeLa cells

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Author(s): Khanna Venkatesan | Kannabiran Krishnan

Journal: International Journal of Green Pharmacy
ISSN 0973-8258

Volume: 3;
Issue: 3;
Start page: 227;
Date: 2009;
Original page

Keywords: Gymnema sylvestre | Eclipta prostrata | anticancer cytotoxic activity | HeLa cells

ABSTRACT
The anticancer-cytotoxic activities of isolated saponins, gymnemagenol (C 30 H 50 O 4 ) from Gymnema sylvestre and dasyscyphin C (C 28 H 40 O 8 ) from Eclipta prostrata leaves were tested under in vitro conditions in HeLa cells. The gymnemagenol and dayscyphin C at 50 μg/ml showed a good cytotoxic activity (63% and 52%, respectively) in HeLa cells at 48 hours with the IC50 value of 37 and 50 μg/ml, respectively. 5-Fluorouracil (5-FU), a positive control, showed 57.5 % cell death with the IC50 value of 36 μg/ml. The percentage of HeLa cell death was maximum (73%) after 96 hours with gymnemagenol, whereas dasyscyphin C showed only 53%. The isolated saponins were not toxic to Vero cells. From this study, it can be concluded that the saponins, gymnemagenol, and dayscyphin C have significant anticancer-cytotoxic activity on HeLa cells under in vitro conditions.
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