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Anticarcinogenic Activity of Leptadenia reticulata against Dalton’s Ascitic Lymphoma

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Author(s): L. Sathiyanarayanan | Sinnathambi Arulmozhi | N. Chidambaranathan

Journal: Iranian Journal of Pharmacology and Therapeutics
ISSN 1735-2657

Volume: 6;
Issue: 2;
Start page: 133;
Date: 2007;
Original page

Keywords: Leptadenia reticulata | Dalton’s Ascitic Lymphoma | Anticancer agents

ABSTRACT
The aim of the present study is to evaluate the effect of ethanolic extract of leaves of Leptadenia reticulata leaves (LELR) against Dalton’s Ascitic Lymphoma (DAL) in Swiss Albino mice. DAL cells were injected intraperitoneally (106 cells/mouse) to the mice. Two days after cells injection the animals were treated with 200 mg/kg of LELR for 8 days. Five-fluorouracil (20 mg/kg) was used as reference drug. On day 11, cancer cell number, packed cell volume, decrease in tumour weight of the mice, increase in life span and hematological parameters were evaluated and compared with the same parameters in controls. A significant increase in the life span and a decrease in the cancer cell number and tumour weight were noted in the tumour-induced mice after treatment with LELR. The hematological parameters were also normalized by LELR in tumour-induced mice. These observations are suggestive of the protective effect of LELR against Dalton’s Ascitic Lymphoma (DAL).

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