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Anticonvulsant activity of Artemisia nilagirica leaves

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Author(s): A. Vijayalakshmi*, V. Ravichandiran, KV. Durga Prasad, A. Kiran Kumar, K. Rakesh, K. Ramesh Naidu and K. Shravya vardhan

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 9;
Start page: 2881;
Date: 2011;
Original page

Keywords: Epilepsy | Artemisia nilagirica | neurotoxicity | Anticonvulsant

ABSTRACT
The aim of the present study was to evaluate the anticonvulsant activity and neurotoxicity of methanol extract of Artemisia nilagirica leaf and itsethyl acetate fraction in mice. Methods: The anticonvulsant activities of ethanol extract and its ethyl acetate fraction were studied against maximal electroshock(MES) and pentylenetetrazole (PTZ)-induced seizures in mice and neurotoxicity was determined using rotarod test. Results: The duration of hindleg extensionin MES test was reduced significantly (P< 0.001) by both methanol extract at higher dose level of 400 mg/kg and ethyl acetate fraction at the dose level of 200and 400 mg/kg. In PTZ model, the seizure latency was prolonged by all the test groups. Conclusion: Artemisia nilagirica leaf contains pharmacologically activesubstance(s) that may be valuable in the treatment of convulsive disorders, especially petit mal and grand mal seizures.
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