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Anticonvulsant activity of a Mimusops elengi in experimental animals.

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Author(s): Gayatri Ganu *1, Aniket Garud1, Vicky Agarwal1, Sandeep Talele1, Suresh Jadhav2, Ajay Kshirsagar1.

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 9;
Start page: 2938;
Date: 2011;
Original page

Keywords: Mimusops elengi | anticonvulsant | Isoniazid (INH) | Maximal electric shock (MES)

ABSTRACT
Mimusops elengi Linn (Sapotaceae) commonly known as Bakul, is a small to large evergreen tree. It is cultivated in gardens as an ornamental tree. Bark is usedas a tonic, febrifuge, against odontopathy, inflammation. Flowers are brain tonic and are useful as snuff to relieve cephalalgia. It is a rich source of tannin,saponin, alkaloids, glycoside. Mimusops elengi is appeared to be a good source of natural antioxidant. The existing line of treatment for anxiety andconvulsions presents number of limitations with respect to side effects. Remedies from natural origin have drawn attention in the recent times because of multifactorial mechanisms with minimum of side effects. In the present investigation an attempt was made to evaluate anticonvulsant activity of 50,100, 200 mg/kg methanolic, aqueous, and n- butanolic extract of bark of Mimusops elengi respectively.
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