Academic Journals Database
Disseminating quality controlled scientific knowledge

ANTICONVULSANT ACTIVITY OF MORINGA OLEIFERA LEAF

ADD TO MY LIST
 
Author(s): Amrutia Jay N | Lala Minaxi | Srinivasa U. | Shabaraya A. R. | Moses Rajan Semuel

Journal: International Research Journal of Pharmacy
ISSN 2230-8407

Volume: 2;
Issue: 7;
Start page: 160;
Date: 2011;
VIEW PDF   PDF DOWNLOAD PDF   Download PDF Original page

Keywords: Moringa oleifera leaves | anticonvulsant activity | pentylenetetrazole | maximal electroshock.

ABSTRACT
Moringa oleifera which is commonly known as drumstick tree has been used for its nutrition value and extensively used as a CNS depressant traditionally. Present work has been carried out to evaluate the anticonvulsant activity of methanolic extract of M. oleifera leaves against pentylenetetrazole (PTZ) and maximal electroshock (MES) induced convulsions at different dose level (200 mg/kg and 400 mg/kg i.p.). Diazepam and phenytoin (5mg/kg i.p. and 25mg/kg i.p., respectively) were used as a reference standard. At both the doses it significantly (P < 0.0001) delayed the onset of clonic seizures in PTZ induced convulsions and significantly reduced (P < 0.0001) duration of hind limb extension in MES test. The phytochemical investigation of plant revealed the presence of alkaloids, flavonoids, tannins and saponins as major constituents. The data obtained indicates that methanolic extract of M. oleifera leaves may help to control grand mal and petit mal epilepsy.

Tango Jona
Tangokurs Rapperswil-Jona

     Save time & money - Smart Internet Solutions