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Antidiabetic Activity of Vinca rosea Extracts in Alloxan-Induced Diabetic Rats

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Author(s): Mohammed Fazil Ahmed | Syed Mohammed Kazim | Syed Safiullah Ghori | Syeda Sughra Mehjabeen | Shaik Rasheed Ahmed | Shaik Mehboob Ali | Mohammed Ibrahim

Journal: International Journal of Endocrinology
ISSN 1687-8337

Volume: 2010;
Date: 2010;
Original page

ABSTRACT
The present study was carried out to evaluate the antidiabetic activity of Vinca rosea methanolic whole plant extracts in alloxan induced diabetic rats for 14 days. The methanolic whole plant extract at high dose (500 mg/kg) exhibited significant anti-hyperglycemic activity than whole plant extract at low dose (300 mg/kg) in diabetic rats. The methanolic extracts also showed improvement in parameters like body weight and lipid profile as well as regeneration of β-cells of pancreas in diabetic rats. Histopathological studies reinforce the healing of pancreas, by methanolic Vinca rosea extracts, as a possible mechanism of their antidiabetic activity.
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