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ANTIDIABETIC AND ANTIHYPERLIPIDAEMIC EFFECT OF POLYGALA JAVANA DC ON ALLOXAN INDUCED DIABETIC RATS

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Author(s): Alagammal M | Agnel Ruba A | Mohan VR

Journal: International Research Journal of Pharmacy
ISSN 2230-8407

Volume: 3;
Issue: 9;
Start page: 231;
Date: 2012;
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Keywords: Antihyperlipidaemic | Antidiabetic | P.javana | Alloxan and Glibenclamide.

ABSTRACT
The ethanol extract of Polygala javana whole plant (Family: Polygalaceae) was investigated for it antidiabetic and antihyperlipidaemic effect in Wistar Albino rats. Diabetes was induced in albino rats by administration of alloxan monohydrate (150mg/kg, i.p). The ethanol extracts of Polygala javana at a dose of 100 and 200mg/kg of body weight were administered at single dose per day to diabetes induced rats for a period of 14 days. The effect of ethanol extract of Polygala javana whole plant extract on blood glucose, serum insulin, urea, creatinine, glycosylated haemoglobin, serum lipid profile [total cholesterol (TR), triglycerides (TG), low density lipoprotein – cholesterol (LDL-C), very low density lipoprotein – cholesterol (VLDL-C), high density lipoprotein – cholesterol (HDL-C) and phospholipid (PL)] serum protein, albumin, globulin, serum enzymes [serum glutamate pyruvate transaminases (SGPT), and serum glutamate oxaloacetate transaminases (SGOT), and alkaline phosphatase (ALP)], were measured in the diabetic rats. The ethanol extract of Polygala javana whole plant elicited significant reductions of blood glucose (P
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