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Antidiabetic, Hypolipidemic activity of Adenanthera pavonina seeds in alloxan induced diabetic rats.

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Author(s): A.Krishnaveni#, Dr.S.Selvi, Dr.S. Mohandass

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 5;
Start page: 1440;
Date: 2011;
Original page

Keywords: Adenanthera pavonina | diabetes | hypolipidemic | alloxan.

ABSTRACT
Diabetes mellitus is a disease characterized by chronic hyperglycemia and glucosuria produced by an absolute or relative insufficiency of insulin. The ailment may result into the development of further metabolic and anatomic disturbances among which is lipemia, hypercholesterolemia, loss of weight, ketosis, atherosclerosis, pathologic changes in the eye, neuropathy, renal disease and coma. Medicinal plants were used right from the day of mankind in evaluation for drugs and these have no side effects compared to that of chemically synthesized drugs. In the present study, hyperglycemia in rats was induced by intraperitoneal injection of freshly prepared alloxan monohydrate. Group I, normal control rats; Group II and III are normal rats treated with aqueous and alcoholic extract of Adenanthera pavonina (500mg/kg) seeds respectively, Group IV served as diabetic control rats(160mg/dl), Group V and VI are diabetic rats treated with aqueous and alcoholic extract of seeds of Adenanthera pavonina (500mg/kg) for 10 days respectively. At the end of experimental period, rats were sacrificed by cervical decapitation and blood samples were collected and analyzed for biochemical parameters. Group V and Group VI produced significant reversal in hyperglycemic status. It also produced significant beneficial effects on lipid profile in diabetes rats i.e. reduction in total Cholesterol, Triglycerides, LDL and increasing HDL significantly. Therefore, it was likely that aqueous and alcoholic extract of Adenanthera pavonina seeds produced favorable changes in the lipid profile in diabetic rats along with better glycemic control.
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