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Antidiarrheal Evaluation of Benincasa hispida (Thunb.) Cogn. Fruit Extracts

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Author(s): Vrushabendra Swamy | Sridhar Chandanam | Sreenivasa Rao | R Dhanapal | V Balamuralidhar | Ashoka Babu

Journal: Iranian Journal of Pharmacology and Therapeutics
ISSN 1735-2657

Volume: 4;
Issue: 1;
Start page: 24;
Date: 2005;
Original page

Keywords: Benicasa hispida | Antidiarrheal | Fruits | BHFE

ABSTRACT
The methanolic extract of fruit of Benincasa hispida (BHFE) was evaluated for its antidiarrheal potential against several experimental models of diarrhea in rats. BHFE treated animals showed significant inhibi-tory activity against castor oil induced diarrhea and inhibited PGE2 induced enter pooling in rats. It also showed significant reduction in gastro intestinal motility following charcoal meal in rats. The result ob-tained and establishes the efficacy of BHFE as an antidiarrheal agent.

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