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Antiepileptic Drug Discovery and Development: What Have We Learned and Where Are We Going?

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Author(s): Aaron C. Gerlach | Jeffrey L. Krajewski

Journal: Pharmaceuticals
ISSN 1424-8247

Volume: 3;
Issue: 9;
Start page: 2884;
Date: 2010;
Original page

Keywords: epilepsy | antiepileptic | AED | seizure | anticonvulsant

ABSTRACT
Current marketed antiepileptic drugs (AEDs) consist of a variety of structural classes with different mechanisms of action. These agents typically have non-overlapping efficacy and side-effect profiles presenting multiple treatment options for the patient population. However, approximately 30% of seizure sufferers fail to respond to current therapies often because poorly tolerated side-effects limit adequate dosing. The scope of this review is to summarize selected advances in 2nd and 3rd generation AEDs as well as compounds in development with novel mechanisms of action.
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