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Antifertility activity of ethanolic extracts of Plumbago indica and Aerva lanata on albino rats

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Author(s): Savadi R | Alagawadi K

Journal: International Journal of Green Pharmacy
ISSN 0973-8258

Volume: 3;
Issue: 3;
Start page: 230;
Date: 2009;
Original page

Keywords: Plumbago indica | Aerva lanata | anti-implantation | abortifacient | spermatozoa

ABSTRACT
The ethanolic extract of roots of Plumbago indica and aerial parts of Aerva lanata were evaluated for antifertility activity using anti-implantation, abortificient, and motility of rat spermatozoa (in-vitro) models. The anti-implantation effect seems to be depending on the dose as well as the initiation of treatment on specific days of pregnancy. P. indica has showed percentage pre-implantation loss of 40% and 50% against control at the doses of 200 and 400 mg/kg b/w. Percentage pregnancy failure among treated groups was 60% and 70% at the doses of 200 and 400 mg/kg b/w, whereas A. lanata has shown pre-implantation loss of 20% and 30% against control at the dose of 200 and 400 mg/kg b/w, respectively. Percentage pregnancy failure among treated groups was 30% and 40% at the dose of 200 and 400 mg/kg b/w, respectively. Both P. indica and A. lanata at a concentration of 10% have shown no motility of rat spermatozoa within 60 seconds.
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