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Antigen specific cellular response in patients with Hepatitis C virus infection and its association with HLA alleles

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Author(s): Chinmaya Mahapatra | Anuradha S Tripathy

Journal: International Journal of Collaborative Research on Internal Medicine & Public Health
ISSN 1840-4529

Volume: 3;
Issue: 3;
Start page: 273;
Date: 2011;
Original page

Keywords: HCV-Hepatitis C virus - human leukocyte antigen - HLA A*03 | A*32 | B*15 | B*55 | Cw*18 - western India

ABSTRACT
Background & objectives: Host genetic diversity is believed to contribute to the spectrum of clinicaloutcomes in hepatitis C virus (HCV) infection. The present study aimed at finding out the frequencies ofHLA class I alleles of HCV infected individuals from western India (Maharashtra state).Methods: Forty three clinically characterized anti-HCV positive patients from Maharashtra were studiedfor HLA A, B, C alleles by PCR- sequence specific primer (SSP) typing method and compared with 67and 113 ethnically matched, anti-HCV negative healthy controls from western India(Maharashtra state).Results: Our analysis revealed an association of HLA alleles HLA A*03 (OR= 16.69, EF, 0.44, P=7.9E-12), A*32 (OR= 1474, EF 0.21, P=1.8E-9), HLA B*15 (OR=14.11, EF 0.39, P=2.18E-10), B*55 (OR=12.09,EF 0.07, P=0.005), Cw*16 (OR= 7.45, EF 0.12, P=0.001), Cw*18 (OR= 402, EF 0.05, P=0.003),with HCV infection, chronicity.Interpretation & conclusions: Our results suggest that the establishment of viral persistence in patientsis due to a failure of the immune response and is associated with HLA class 1 allele mainly A*03, A*32,B*15, B*55, Cw*16, Cw*18 restricted individuals, as indicated by the absence of a significant T-cellresponse thus this proves that associated haplotype influence HCV infection as a host genetic factor.
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