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Antihyperglycemic activity of the ethanolic seed extract of Vernonia anthelminticum willd

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Author(s): Karthikeyan A | Siva G | Sujitha S | Rex DAP | Chidambaranathan N

Journal: International Journal of Green Pharmacy
ISSN 0973-8258

Volume: 2;
Issue: 4;
Start page: 209;
Date: 2008;
Original page

Keywords: Alloxan | antidiabetic | blood glucose | gliclazide | vernonia anthelminiticum

ABSTRACT
The investigation was carried out to study the effects of Vernonia anthelminticum Willd seed extract on blood glucose level. The antihyperglycemic efficacy of the ethanolic extract of the seed was evaluated in normal, glucose and alloxan induced diabetic rats. The extract exhibited significant hypoglycemic activity in all three animal models when compared with the control group. The activity was also comparable to that of the effect produced by a standard antidiabetic agent gliclazide, 25 mg/kg (p.o.). The results also indicated dose dependent effect. The hypoglycemia and antihyperglycaemia produced by the extract may be due to increased uptake of glucose at tissue level or increase in pancreatic beta-cell function or due to inhibition of intestinal absorption of glucose. The study indicated that the ethanolic extract is a potential antidiabetic agent and lends scientific support for its elseā€²s in folk medicine.
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