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Antihypertensive Effect of Long-Term Oral Administration of Jellyfish (Rhopilema esculentum) Collagen Peptides on Renovascular Hypertension

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Author(s): Yongliang Zhuang | Liping Sun | Yufeng Zhang | Gaoxiang Liu

Journal: Marine Drugs
ISSN 1660-3397

Volume: 10;
Issue: 2;
Start page: 417;
Date: 2012;
Original page

Keywords: jellyfish | collagen peptide | blood pressure | angiotensin II | kidney

ABSTRACT
Antihypertensive effect of long-term oral administration of jellyfish (Rhopilema esculentum) collagen peptides (JCP) on renovascular hypertension rats (RVHs) was evaluated. The systolic blood pressure and diastolic blood pressure of the RVHs were significantly reduced with administration of JCP (p < 0.05), compared with model control group. However, the arterial blood pressure of normal rats showed no significant changes during long-term oral treatment with high dose JCP (p > 0.05). Furthermore, effect of JCP on angiotensin II (Ang II) concentration of plasma had no significance (p > 0.05), but JCP significantly inhibited the Ang II concentration in RVHs’ kidney (p < 0.05). The kidney should be the target site of JCP.
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