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ANTILIPIDPEROXDATIVE ROLE OF FLAVONOID FRACTION OF CYNODON DACTYLON AGAINST ELA MEDIATED CELL DAMAGE

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Author(s): Saroja M | Annapoorani S

Journal: International Research Journal of Pharmacy
ISSN 2230-8407

Volume: 3;
Issue: 1;
Start page: 181;
Date: 2012;
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Keywords: Antioxidants | Silymarin | ELA | flavonoid fraction | lipid peroxidation.

ABSTRACT
A study was undertaken to evaluate the antilipid peroxidative role of flavonoid fraction of Cynodon dactylon in ELA implanted Swiss albino mice. In this present study mice were divided into the seven groups and each group containing 6 mice. Group I,II and III were received (i.p) 0.1 ml of PBS, Paraffin oil and DMSO respectively which served as control mice. Group IV mice were administered(i.p) with 25 mg of Silymarin: Group V mice were treated with 80 μl of flavonoid fraction of cynodon dactylon (Cdff) (i.p): Group VI mice were received 1x106 ELA tumor cells and ED50 80 μl of flavonoid fraction of C. dactylon (i.p). Group VII received 1x106 ELA tumor cells (i.p) that served as ELA control. The study was continued for the period of 15,30,45 and 60 days. At the end of each treatment period the mice were sacrificed.The activity of enzymic antioxidants such as Catalase (CAT), Superoxide dismutase (SOD) and glutathione peroxidase (GPX) and the levels of non enzymic antioxidants such as vitamin A, vitamin E and reduced glutathione (GSH) and lipid peroxide (MDA) in the liver homogenate of control and experimental mice were determined. The activities of enzymic antioxidants and the levels of non enzymic antioxidants were decreased in ELA control mice and MDA level was increased. Administration of Cdff significantly altered the antioxidants level and MDA to normal level. The results suggests that Cdff possess antilipidperoxidative effect.
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