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Antimalarial, Anticancer, Antimicrobial Activities and Chemical Constituents of Essential Oil from the Aerial Parts of Cyperus kyllingia Endl.

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Author(s): Sorachai Khamsan | Boonsom Liawruangrath | Saisunee Liawruangrath | Aphiwat Teerawutkulrag | Stephen G. Pyne | Mary J. Garson

Journal: Records of Natural Products
ISSN 1307-6167

Volume: 5;
Issue: 4;
Start page: 324;
Date: 2011;
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Keywords: Cyperus kyllingia Endl. | essential oil | antimalarial activity | anticancer activity | antimicrobial activity

ABSTRACT
The chemical constituents of the essential oil from Cyperus kyllingia Endl. were analyzed by a GC, GC-MS. Twenty-three compounds were identified, accounting for 93.75% of the total oil that consisted mainly of oxygenated sesquiterpenes (53.52%), particularly sesquiterpene hydrocarbons (38.97%), and carboxylic acid (1.26%). The most representative compounds were a -cadinol (19.32 %), caryophyllene oxide (12.17%), a -muurolol (11.58 %), a -humulene (9.85%), and a -atlantone (6.07%). The oil showed significant activities against Plasmodium falcipalum (K1, multi drug resistant strain) and NCI-H187 (Small Cell Lung Cancer) with the IC 50 values of 7.52 and 7.72 µg/mL, respectively. The oilexhibited highly active against Staphylococcus aureus ATCC25923 and moderately active against Escherichia coli ATCC25922, Pseudomonas aeruginosa ATCC27553, Aspergillus flavus and Candida albicans.
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