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Antimicrobial Activity of the Crude Extracts of Compound Ascidians, Didemnum candidum and Didemnum psammathodes (Tunicata: Didemnidae) from Mandapam (South East Coast of India)

Author(s): S. Mohamed Hussain

Journal: Current Research Journal of Biological Sciences
ISSN 2041-076X

Volume: 1;
Issue: 3;
Start page: 168;
Date: 2009;
Original page

Keywords: Antimicrobials | cytotoxicity | marine natural products | Didemnum | tunicates

Many cytotoxic compounds of therapeutic interest have been isolated from marine organisms. In thepresent study two species of compound ascidians Didemnum psammathodes and Didemnum candidum wereassayed for their antimicrobial activity against eight bacterial and four fungal pathogens. The antimicrobialactivity of the crude extract of ascidian shows inhibitory activity against almost all the eight strains. However,D. psammathodes shows prominent antibacterial activity than that of Didemnum candidum. Whereas noremarkable antifungal activity was noticed against the ascidian crude extract. The maximum inhibition zone(15 mm) was observed against Salmonella typhi in the crude methanol extract of D. psammathodes and theminimum inhibition zone (1 mm) was noticed against Vibrio cholera and Staphylococcus aureas in the crudeacetone extract of Didemnum candidum. In D. psammathodes the crude methanol extract the range of inhibitionof the bacteria varied from 2–15 mm with an average of 4.3 mm. According to fungi only Aspergillus niger andPenicillium sp. were showed the trace activity against few crude extract and remaining two fungal pathogensshows negative result. In the present result two way analysis of variance was showing that there was asignificant difference between the extracts as well as the strains (p

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